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Archive for October, 2009
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October 30th, 2009Early life nutrition influences thymic growth in male mice that may be related to the regulation of longevity
October 29th, 2009Nutrition and growth rate during early life can influence later health and lifespan. We previously demonstrated that low birth weight resulting from maternal protein restriction during pregnancy followed by catch-up growth in rodents was associated with shortened lifespan whereas protein restriction and slow growth during lactation increased lifespan. The underlying mechanisms by which these differences arise are unknown. Here we report that maternal protein restriction in mice influences thymic growth in early adult life. Offspring of dams fed a low protein diet during lactation (PLP offspring) showed significant thymic growth from 21 days to 12 weeks of age whereas this was not observed in control mice or offspring of dams fed a low protein diet during pregnancy (recuperated offspring). PCNA and SIRT1 protein levels at 21 days of age were significantly higher in thymus from both PLP (P < 0.001 and P < 0.05 respectively) and recuperated mice (P < 0.001 and P < 0.01 respectively) compared to controls. At 12 weeks PLP maintained a higher SIRT1 level whereas PCNA was decreased in thymus from recuperated offspring. This suggests that mitotic activity was initially enhanced in thymus of both PLP and recuperated offspring but remained sustained into adulthood only in PLP mice. The differential mitotic activity in thymus of PLP and recuperated animals appeared to be influenced by changes in sex hormone concentrations and expression of p53, p16, the androgen receptor, IL-7 and the IL-7 receptor. The differential thymic growth may contribute to the regulation of longevity by maternal diet.
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Early life nutrition influences thymic growth in male mice that may be related to the regulation of longevity
Joost Oppenheim, M.D., Laboratory Chief – NCI, to give Keynote Presentation at GTCbio’s 8th Cytokines and Inflammation Conference on January 28-29,…
October 29th, 2009A keynote presentation on a group of structurally diverse multifunctional host proteins called “alarmins”, at GTCbio’s 8th Cytokines and inflammation Conference on January 28-29, 2010 in San Diego, CA.
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Joost Oppenheim, M.D., Laboratory Chief – NCI, to give Keynote Presentation at GTCbio’s 8th Cytokines and Inflammation Conference on January 28-29,…
E-CigaretteDirect.com Urges Latinos To Quit Smoking
October 29th, 2009The leading cause of death for Latinos is tobacco.
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E-CigaretteDirect.com Urges Latinos To Quit Smoking
Progress Made in Spinal Cord Injury Research
October 29th, 2009Researchers in San Diego might have discovered a way to do what was previously thought impossible: to train nerves to properly regenerate themselves.
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Progress Made in Spinal Cord Injury Research
Arbour Group Presents Oracle Validation Solutions to Industry Strategy Council
October 28th, 2009Arbour Group participated in the Life Sciences Industry Strategy Council (ISG) meeting held at Oracle’s New York headquarters.
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Arbour Group Presents Oracle Validation Solutions to Industry Strategy Council
Disrupting sleep causes problems for the body and brain
October 26th, 2009Modern life disrupts our natural sleep cycles with shift-work, jet lag and ubiquitous electric lighting, among other things. New research in mice suggests that the resulting disturbance of nature’s circadian rhythms could have major effects on the body and brain, from a slowing of metabolism to impaired thinking and poor impulse control.
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Disrupting sleep causes problems for the body and brain
The development of hepatic fibrosis occurs normally in AMPK deficient mice
October 26th, 2009Inhibition or blockade of hepatic stellate cells (HSCs), the main matrix producing cells involved in would healing response, represents an attractive strategy for the treatment of liver fibrosis. In vitro studies have shown that activation of the AMP-activated protein kinase (AMPK), a key player in the regulation of cellular energy homeostasis, inhibits proliferation of myofibroblasts derived from HSC. If AMPK is a true regulator of fibrogenesis then defective AMPK activity would enhance fibrogenesis and hepatic fibrosis. To test this, in vitro studies were performed on mouse primary HSCs treated or not with AMPK activator AICAR or isolated from mice lacking the AMPKα1 catalytic subunit (AMPKα1-/-) or their littermates (AMPKα1+/+). Liver fibrosis was induced in vivo in AMPKα1-/- and +/+ mice by repeated injections of CCl4. During culture activation of HSC, AMPK protein and activity significantly increased and regulatory AMPKγ3 mRNA was specifically up-regulated. Stimulation of AMPK activity by AICAR inhibited HSC proliferation, as expected, as well as collagen-α1 expression. Importantly, AMPKα1 deletion inhibited proliferation of HSC, but not fibrogenesis in vivo. Moreover, AMPKα1 deletion was not associated with enhanced carbon tetrachloride-induced fibrosis in vivo. Our data demonstrate that HSC trans-differentiation is associated with increased AMPK activity that could relate to the stabilization of AMPK complex by the γ3 subunits. Activation of AMPK in HSC inhibits in vitro fibrogenesis. By contrast low AMPK activity does not prevent HSC activation in vitro nor in vivo fibrosis.
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The development of hepatic fibrosis occurs normally in AMPK deficient mice
Proteome Solutions Announces ProteinID Finder version 1.7.0
October 25th, 2009Proteome Solutions today announces the availability of ProteinID Finder version 1.7.0 (v1.7.0).
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Proteome Solutions Announces ProteinID Finder version 1.7.0
Court Vindicates Doctor Who Questioned Pregnancy "Miracle" Report, Throws Out Kwang Yul Cha’s Lawsuit
October 25th, 2009Today the California Court of Appeals, “affirmed in full” a 2008 Superior Court decision and thus ruled that Superior Court Judge James Dunn had acted appropriately in tossing out Dr.
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Court Vindicates Doctor Who Questioned Pregnancy "Miracle" Report, Throws Out Kwang Yul Cha’s Lawsuit
Homemade Algae Photobioreactor Holds the Future of the World’s Resources
October 25th, 2009If you were to ask any conservationist to choose one of Mother Nature’s natural resources that would help change the future of how the world does business, chances are they’d point to algae.
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Homemade Algae Photobioreactor Holds the Future of the World’s Resources
Skila Closes Quarter with 9 Expansion Deals with 5 Clients
October 23rd, 2009Skila, A Sela2 Company, has recently expanded its active client base by closing nine expansions across five current clients in Q4 of its fiscal year, ending September 30, 2009.
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Skila Closes Quarter with 9 Expansion Deals with 5 Clients
2009 Pearl Meister Greengard Prize goes to pioneering geneticist
October 22nd, 2009The 2009 Pearl Meister Greengard Prize recognizes Suzanne Cory, a world-renowned geneticist and pioneering scientific leader. The first woman to serve as director of Australia’s prestigious Walter and Eliza Hall Institute, she has been an influential force in shaping science policy in her nation.
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2009 Pearl Meister Greengard Prize goes to pioneering geneticist
CID Bio-Science, Inc. How to Operate CI-202
October 21st, 2009Copyright 2009, CID Bio-Science, Inc. www.cid-inc.com ————————————- Video by GT1 Video www.gt1video.com
Checkered history of mother and daughter cells explains cell cycle differences
October 20th, 2009In preparing to divide, mother and daughter cells use different gears and levers to regulate their genes. A collaboration between two geneticists and their labs now reveals that this difference in gene expression ultimately affects the protein CLN3, the levels of which certify whether a cell is ready to commit to another grueling round of cell division. The work sets a new compass point for studying how cell division may go awry in different types of cancer.
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Checkered history of mother and daughter cells explains cell cycle differences
