Posts Tagged ‘analysis’

Bioscience Valuation

July 11th, 2010

Bioscience Valuation is a management consulting firm with a focus on biotechnology and pharmaceuticals.The company is specialized in the analysis and quantitative as …

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Bioscience Valuation

Prognostic value of admission blood glucose concentration and diabetes diagnosis on survival after acute myocardial infarction; Results from 4702…

October 13th, 2009

The diagnosis of diabetes and admission blood glucose concentration are associated with adverse outcome after acute coronary syndromes. We compared the relative association with survival after ST-elevation acute myocardial infarction of admission blood glucose concentration and of diabetes diagnosis.
We carried out a retrospective cohort study in 4702 consecutive patients with ST elevation AMI (STEMI) occurring April 1st 1993 – December 31st 2005, assessed for mortality at 30 days and 1 year. Patients were classified according to antecedent diabetes, and by blood glucose concentration at admission (quartile 1, <7mmol/L; quartile 2, 7 – 8.2 mmol/L; quartile 3, 8.3 – 10.9 mmol/L; quartile 4, ≥11 mmol/L). Multivariable models were constructed for determinants of mortality, including year of STEMI and demographic variables, entering blood glucose concentration and antecedent diabetes individually, and together.
All-cause 30-day and 1-year mortality were 22.8% and 31.3% for patients with antecedent diabetes, compared to 16.3% and 23.0% respectively for those without. For glucose quartiles 1, 2, 3, and 4, crude 30-day mortality was 9.0%, 10.6%, 17.9% and 31.0%. Adjusted 30-day mortality risk was similar in quartile 2, higher by >80% in quartile 3 and by >150% in quartile 4, compared to glucose quartile 1. Antecedent diabetes was associated with an increase in mortality (unadjusted odds ratio (OR) 1.52 (95% CI 1.24 , 1.86)). On multivariable analysis (excluding glucose quartile), this reduced to 1.24 (0.98 , 1.58) and changed to a small, statistically non-significant reduction in risk when glucose quartile was added to the analysis (adjusted OR 0.87 (0.67 , 1.13)). Inclusion of antecedent diabetes in multivariable models did not add to the predictive value for mortality of glucose quartile (p=0.368). Similar relationships were observed for 1 year mortality.
In patients with STEMI, blood glucose concentration shows graded association with risk of 30-day and 1-year mortality and is of greater prognostic relevance than antecedent diabetes diagnosis. Moderate elevation of blood glucose, below levels previously considered to be clinically relevant, is associated with adverse impact on survival.

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Prognostic value of admission blood glucose concentration and diabetes diagnosis on survival after acute myocardial infarction; Results from 4702…

Bioscience Technician – Wisconsin Technical Colleges

September 30th, 2009

Research a career in Bioscience for challenging and rewarding work.

Xradia Launches Website With Stunning 3D Image and Movie Gallery

July 21st, 2009

Comprehensive X-ray Imaging Information for Advanced Materials RandD, Biomedical Research, Drilling Feasibility Analysis for Oil and Gas, Nanotechnology, and Semiconductor Package Failure Analysis

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Xradia Launches Website With Stunning 3D Image and Movie Gallery

Measuring interdisciplinary research: analysis of co-authorship for research staff at the University of York

June 9th, 2009

Collaboration allows researchers to combine the strength of different disciplines to undertake research that neither could do individually. Scientific collaboration can be examined by analysing patterns of co-authorship of papers in publication databases (e.g. Web of Science) using methods from Social Network Analysis. In this project, I describe three networks consisting of researchers in the Biology and Chemistry Departments at the University of York to investigate degree, degree distribution, key brokers and preference of researchers for collaborating within or outside their own research field. Clustering (or transitivity) was used to describe whether collaboration is more likely if two researchers have a collaborator in common. To introduce a control and realize the significance of the results produced, a network consisting of 98 researchers from the Chemistry and Biology departments was produced and compared with a distribution of 1000 ER random graphs for degree, transitivity and betweenness. We find that researchers in the Department of Biology (50 researchers) have fewer collaborations with their departmental colleagues than those in the Department of Chemistry (45 researchers): the average number of links each researcher had with others in the Biology collaboration network was 2.6, the corresponding values for Chemistry were 4.8 links per researcher. We also find that researchers within the Chemistry department were more likely than their colleagues in Biology to collaborate with another researcher if they had a collaborator in common. One aim of the study was to characterize the extent of interdisciplinary research within the Department of Biology. Staff in the Biology department were categorized into distinct research foci, indicating the discipline of the researcher. There were many links from the Bioinformatics and Mathematics, and Biophysics and Biochemistry foci, to other foci, implying that staff within these foci were interdisciplinary in their research—indicative of their role in providing techniques or tools that are applicable across discipline boundaries. This sort of analysis provides quantitative evidence to understand the social patterns of scientific collaboration and may be a useful tool in the development of strategies to promote interdisciplinary research within research institutions.

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